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Alireza Haghighi

M.D., L.L.B., D.Phil., FACMG

Director, International Center for Genetic Disease, Harvard Medical School

Principal Investigator and Director, Bahrain National Genome Program at Harvard

Assistant Professor of Medicine, Harvard Medical School

Dr. Haghighi is an Assistant Professor and clinician-scientist in the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School. He is an American board-certified geneticist. He completed his graduate and clinical training at University of Oxford, and Harvard Medical School. Dr. Haghighi is the Founding Director of BWH International Center for Genetic Disease (iCGD), and the PI and Director of the National Genome Project of Bahrain (Phase I: ~$10M) at Harvard.

For his research, he investigates the genetic basis for human disease, with a focus on cardiovascular disease (e.g., cardiomyopathies, and congenital heart disease) and translating the research discoveries into better diagnostics and improved patient care. He is the PI on two NIH- and AHA-funded projects for investigating the genetics of unexplained cardiomyopathies in adult and children. He is also the Director of GEnetics NEtwork in the Middle East and Africa (GENE-ME), a large clinical research network for genetic studies in those regions that aims to: (1) identify novel disease-causing mutations and genotype-phenotype correlations, and (2) advance genomic medicine in the Middle East and Africa through capacity building.

Dr. Haghighi has led many international projects for advancing medical science in different countries to improve the health and well-being of people. He is the Founding President of Advancement Initiative for Medicine and Science (AIMS), a global foundation that brings together academics and physicians and is dedicated to advancing medical science and healthcare around the world.

He has received many awards for his research and international projects, including the International Genetic Disorders Prevention Award in 2018 (for outstanding contributions to and scientific excellence in genetic research), the Global Health Pioneer Award in 2019 (for significant contribution to improving the quality of life through innovation and capacity building).

Contact Infomation

Email:

ahaghighi@bwh.harvard.edu

Alireza Haghighi

M.D., L.L.B., D.Phil., FACMG

Director, International Center for Genetic Disease, Harvard Medical School

Principal Investigator and Director, Bahrain National Genome Program at Harvard

Assistant Professor of Medicine, Harvard Medical School

Dr. Haghighi is an Assistant Professor and clinician-scientist in the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School. He is an American board-certified geneticist. He completed his graduate and clinical training at University of Oxford, and Harvard Medical School. Dr. Haghighi is the Founding Director of BWH International Center for Genetic Disease (iCGD), and the PI and Director of the National Genome Project of Bahrain (Phase I: ~$10M) at Harvard.

For his research, he investigates the genetic basis for human disease, with a focus on cardiovascular disease (e.g., cardiomyopathies, and congenital heart disease) and translating the research discoveries into better diagnostics and improved patient care. He is the PI on two NIH- and AHA-funded projects for investigating the genetics of unexplained cardiomyopathies in adult and children. He is also the Director of GEnetics NEtwork in the Middle East and Africa (GENE-ME), a large clinical research network for genetic studies in those regions that aims to: (1) identify novel disease-causing mutations and genotype-phenotype correlations, and (2) advance genomic medicine in the Middle East and Africa through capacity building.

Dr. Haghighi has led many international projects for advancing medical science in different countries to improve the health and well-being of people. He is the Founding President of Advancement Initiative for Medicine and Science (AIMS), a global foundation that brings together academics and physicians and is dedicated to advancing medical science and healthcare around the world.

He has received many awards for his research and international projects, including the International Genetic Disorders Prevention Award in 2018 (for outstanding contributions to and scientific excellence in genetic research), the Global Health Pioneer Award in 2019 (for significant contribution to improving the quality of life through innovation and capacity building).

Recent Publications

Demographic and Viral-Genetic Analyses of COVID-19 Severity in Bahrain Identify Local Risk Factors and a Protective Effect of Polymerase Mutations

Published On 2022 Aug 29

Journal article

A multitude of demographic, health, and genetic factors are associated with the risk of developing severe COVID-19 following infection by the SARS-CoV-2. There is a need to perform studies across human societies and to investigate the full spectrum of genetic variation of the virus. Using data from 869 COVID-19 patients in Bahrain between March 2020 and March 2021, we analyzed paired viral sequencing and non-genetic host data to understand host and viral determinants of severe COVID-19. We...


Genetic Determinants of Sudden Unexpected Death in Pediatrics

Published On 2022 Jan 14

Journal article

CONCLUSION: We provide strong evidence for a role of genetic factors in SUDP, involving both candidate genes and novel genes for SUDP and expanding phenotypes of disease genes not previously associated with sudden death.