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Amirreza Haghighi

M.D., M.Sc.

Lecturer on Medicine, Harvard Medical School

Director for Research, International Center for Genetic Disease

Senior Scientist, Department of Medicine

Brigham and Women’s Hospital

Harvard Medical School



Dr. Amirreza Haghighi is a Lecturer on Medicine at Harvard Medical School, a Senior Scientist in the Department of Medicine, Brigham and Women's Hospital, and the Director for Research, International Center for Genetic Disease, Harvard Medical School.  He investigates the genetic basis of human disease and translates the findings into better diagnostics and improved patient care.  His studies have aimed to identify new genes responsible for a number of conditions from complex disorders to Mendelian diseases.  He also directs the International Genomic Medicine Courses which specifically focus on strategies and knowledge for clinical management of genetic disorders and on the analysis of genetic test results.


His research on common diseases has focused on obesity.  He has investigated the genetic and environmental factors underlying obesity.  For example, his GWA analyses showed that OPRM1 modulates dietary intake of fat and hence risk for obesity, and this effect may be modulated by subtle variations in the amygdala volume.  He led a cross-sectional study of a population-based cohort to analyze the association between maternal smoking and obesity, and showed that prenatal exposure to maternal cigarette smoking may promote obesity by enhancing dietary preference for fat, and this effect may be mediated in part through subtle structural variations in the amygdala.


Dr. Haghighi uses different genomic technologies, including whole genome, exome, and RNA sequencing to investigate Mendelian disease with focus on the genetics of inherited conditions of the kidney (e.g., polycystic kidney disease, PKD) and liver (e.g. polycystic liver disease, PLD).


Dr. Haghighi has been actively involved in participating in and leading the international projects.  He is a research investigator and the Research Director of GENetics of NEtwork in the Middle East (GENE-ME).








Contact Infomation

Email:

arhaghighi@bwh.harvard.edu

Amirreza Haghighi

M.D., M.Sc.

Lecturer on Medicine, Harvard Medical School

Director for Research, International Center for Genetic Disease

Senior Scientist, Department of Medicine

Brigham and Women’s Hospital

Harvard Medical School



Dr. Amirreza Haghighi is a Lecturer on Medicine at Harvard Medical School, a Senior Scientist in the Department of Medicine, Brigham and Women's Hospital, and the Director for Research, International Center for Genetic Disease, Harvard Medical School.  He investigates the genetic basis of human disease and translates the findings into better diagnostics and improved patient care.  His studies have aimed to identify new genes responsible for a number of conditions from complex disorders to Mendelian diseases.  He also directs the International Genomic Medicine Courses which specifically focus on strategies and knowledge for clinical management of genetic disorders and on the analysis of genetic test results.


His research on common diseases has focused on obesity.  He has investigated the genetic and environmental factors underlying obesity.  For example, his GWA analyses showed that OPRM1 modulates dietary intake of fat and hence risk for obesity, and this effect may be modulated by subtle variations in the amygdala volume.  He led a cross-sectional study of a population-based cohort to analyze the association between maternal smoking and obesity, and showed that prenatal exposure to maternal cigarette smoking may promote obesity by enhancing dietary preference for fat, and this effect may be mediated in part through subtle structural variations in the amygdala.


Dr. Haghighi uses different genomic technologies, including whole genome, exome, and RNA sequencing to investigate Mendelian disease with focus on the genetics of inherited conditions of the kidney (e.g., polycystic kidney disease, PKD) and liver (e.g. polycystic liver disease, PLD).


Dr. Haghighi has been actively involved in participating in and leading the international projects.  He is a research investigator and the Research Director of GENetics of NEtwork in the Middle East (GENE-ME).








Recent Publications

Urinary epidermal growth factor/monocyte chemotactic peptide 1 ratio as non-invasive predictor of Mayo clinic imaging classes in autosomal dominant polycystic kidney disease

Published On 2022 Nov 07

Journal article

CONCLUSION: The ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 is a non-invasive pathophysiological biomarker that can be used for clinical risk stratification in autosomal dominant polycystic kidney disease.


Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease

Published On 2022 Sep 15

Journal article

Autosomal dominant polycystic kidney disease (ADPKD) is the most common Mendelian kidney disease, affecting approximately one in 1,000 births and accounting for 5% of end-stage kidney disease in developed countries. The pathophysiology of ADPKD is strongly linked to metabolic dysregulation, which may be secondary to defective polycystin function. Overweight and obesity are highly prevalent in patients with ADPKD and constitute an independent risk factor for progression. Recent studies have...