Chief Data Officer and Institute Scientist
Co-Director, Eric and Wendy Schmidt Center
Broad Institute of MIT and Harvard
Anthony Philippakis is the chief data officer of the Broad
Institute of MIT and Harvard, and the co-director of the Eric and Wendy Schmidt Center.
He trained as a cardiologist at Brigham and Women’s Hospital, with
a focus on rare genetic cardiovascular diseases. At the Broad Institute he is
the founding director of the Data Sciences Platform, an organization of over
200 software engineers and computational biologists that develops software for
analyzing genomic and clinical data. In addition to his roles at the Broad
Institute and Brigham and Women’s Hospital, Philippakis is a venture partner at
GV, focusing on machine learning, distributed computing, and genomics.
Philippakis received his M.D. from Harvard Medical School and
completed a Ph.D. in biophysics at Harvard. As an undergraduate, he studied
mathematics at Yale University, and later completed the Part III (equivalent to
M.Phil.) in mathematics at Cambridge University.
Chief Data Officer and Institute Scientist
Co-Director, Eric and Wendy Schmidt Center
Broad Institute of MIT and Harvard
Anthony Philippakis is the chief data officer of the Broad
Institute of MIT and Harvard, and the co-director of the Eric and Wendy Schmidt Center.
He trained as a cardiologist at Brigham and Women’s Hospital, with
a focus on rare genetic cardiovascular diseases. At the Broad Institute he is
the founding director of the Data Sciences Platform, an organization of over
200 software engineers and computational biologists that develops software for
analyzing genomic and clinical data. In addition to his roles at the Broad
Institute and Brigham and Women’s Hospital, Philippakis is a venture partner at
GV, focusing on machine learning, distributed computing, and genomics.
Philippakis received his M.D. from Harvard Medical School and
completed a Ph.D. in biophysics at Harvard. As an undergraduate, he studied
mathematics at Yale University, and later completed the Part III (equivalent to
M.Phil.) in mathematics at Cambridge University.
Journal article
Despite advances in managing traditional risk factors, coronary artery disease (CAD) remains the leading cause of mortality. Circulating hematopoietic cells influence risk for CAD separately from traditional risk factors, but the role of a key regulating organ, the spleen, is unknown. The understudied spleen is a representation of the hematopoietic system optimally suited for unbiased radiologic investigations toward mechanistic insights. Here, we leveraged deep learning to extract 107 splenic...
Journal article
High-throughput affinity-based proteomics has advanced biomedical research, yet fundamental, persistent discordance between mainstream platforms (SomaScan and Olink) routinely undermines the replication of findings. This platform-driven non-replication complicates downstream biological validation and biomarker prioritization. Here, we develop a machine learning-based framework for cross-platform protein value imputation to resolve this translational bottleneck. Using paired proteomic data...