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Anthony Philippakis

M.D., Ph.D.

Chief Data Officer and Institute Scientist

Co-Director, Eric and Wendy Schmidt Center

Broad Institute of MIT and Harvard

Anthony Philippakis is the chief data officer of the Broad Institute of MIT and Harvard, and the co-director of the Eric and Wendy Schmidt Center.

He trained as a cardiologist at Brigham and Women’s Hospital, with a focus on rare genetic cardiovascular diseases. At the Broad Institute he is the founding director of the Data Sciences Platform, an organization of over 200 software engineers and computational biologists that develops software for analyzing genomic and clinical data. In addition to his roles at the Broad Institute and Brigham and Women’s Hospital, Philippakis is a venture partner at GV, focusing on machine learning, distributed computing, and genomics.

Philippakis received his M.D. from Harvard Medical School and completed a Ph.D. in biophysics at Harvard. As an undergraduate, he studied mathematics at Yale University, and later completed the Part III (equivalent to M.Phil.) in mathematics at Cambridge University. 

Anthony Philippakis

M.D., Ph.D.

Chief Data Officer and Institute Scientist

Co-Director, Eric and Wendy Schmidt Center

Broad Institute of MIT and Harvard

Anthony Philippakis is the chief data officer of the Broad Institute of MIT and Harvard, and the co-director of the Eric and Wendy Schmidt Center.

He trained as a cardiologist at Brigham and Women’s Hospital, with a focus on rare genetic cardiovascular diseases. At the Broad Institute he is the founding director of the Data Sciences Platform, an organization of over 200 software engineers and computational biologists that develops software for analyzing genomic and clinical data. In addition to his roles at the Broad Institute and Brigham and Women’s Hospital, Philippakis is a venture partner at GV, focusing on machine learning, distributed computing, and genomics.

Philippakis received his M.D. from Harvard Medical School and completed a Ph.D. in biophysics at Harvard. As an undergraduate, he studied mathematics at Yale University, and later completed the Part III (equivalent to M.Phil.) in mathematics at Cambridge University. 

Recent Publications

FAVOR: functional annotation of variants online resource and annotator for variation across the human genome

Published On 2022 Nov 09

Journal article

Large biobank-scale whole genome sequencing (WGS) studies are rapidly identifying a multitude of coding and non-coding variants. They provide an unprecedented resource for illuminating the genetic basis of human diseases. Variant functional annotations play a critical role in WGS analysis, result interpretation, and prioritization of disease- or trait-associated causal variants. Existing functional annotation databases have limited scope to perform online queries and functionally annotate the...


Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease

Published On 2022 Sep 23

Journal article

CONCLUSIONS: Combined monogenic and polygenic assessments for CAD risk provided by preventive genomics clinics are beneficial for patients and result in changes in management in a significant portion of patients.