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Evan Koch

Ph.D.

Postdoctoral Research Fellow

Department of Biomedical Informatics, Harvard Medical School

Dr. Koch is a postdoctoral researcher in the Department of Biomedical Informatics at Harvard Medical School. He works on statistical and theoretical problems in population and evolutionary genetics. His current research projects include using precise mutation rate estimates in the human genome to measure natural selection on a fine scale, and the investigation of selection on human traits using the results of genome-wide association studies. He has also worked on arabidopsis and wolf genetics, and currently has added the SARS-CoV-2 virus to this mix. 

Dr. Koch obtained my PhD in Ecology and Evolution from the University of Chicago, where he was an NSF GRFP fellow. Before that, he graduated from the University of Texas with a BS in Biology (honors), and a certificate in computational science. 

Evan Koch

Ph.D.

Postdoctoral Research Fellow

Department of Biomedical Informatics, Harvard Medical School

Dr. Koch is a postdoctoral researcher in the Department of Biomedical Informatics at Harvard Medical School. He works on statistical and theoretical problems in population and evolutionary genetics. His current research projects include using precise mutation rate estimates in the human genome to measure natural selection on a fine scale, and the investigation of selection on human traits using the results of genome-wide association studies. He has also worked on arabidopsis and wolf genetics, and currently has added the SARS-CoV-2 virus to this mix. 

Dr. Koch obtained my PhD in Ecology and Evolution from the University of Chicago, where he was an NSF GRFP fellow. Before that, he graduated from the University of Texas with a BS in Biology (honors), and a certificate in computational science. 

Recent Publications

Opportunities in proximity modulation: Bridging academia and industry

Published On 2025 Aug 22

Journal article

In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating protein-protein interactions. While we are still learning to harvest this approach, it holds tremendous promise for developing treatments for hitherto undruggable proteins. Here, we discuss how academic efforts and academic-industrial collaboration have...


A compact time-domain diffuse optical tomography system for cortical neuroimaging

Published On 2025 Aug 13

Journal article

Recent years have witnessed a rise in research utilizing neuroimaging for precision neuromedicine, but clinical translation has been hindered by scalability and cost. Time-domain functional near infrared spectroscopy (TD-fNIRS), the gold standard of optical neuroimaging techniques, offers a unique opportunity in this domain since it provides superior depth sensitivity and enables resolution of absolute properties unlike its continuous wave counterparts. However, current TD systems have limited...