Share

George Church

Ph.D.

Director, NHGRI Center for Excellence in Genomic Science

Robert Winthrop Professor of Genetics, Harvard Medical School

Professor of Health Sciences and Technology, Harvard and MIT

Founding Core Faculty and Lead, Wyss Institute, Harvard University

Dr. Church  is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT), a founding member of the Wyss Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic, environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN Projects, and Director of the National Institutes of Health Center for Excellence in Genomic Science. 

Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.

He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.

George Church

Ph.D.

Director, NHGRI Center for Excellence in Genomic Science

Robert Winthrop Professor of Genetics, Harvard Medical School

Professor of Health Sciences and Technology, Harvard and MIT

Founding Core Faculty and Lead, Wyss Institute, Harvard University

Dr. Church  is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT), a founding member of the Wyss Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic, environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN Projects, and Director of the National Institutes of Health Center for Excellence in Genomic Science. 

Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.

He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.

Recent Publications

Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus

Published On 2024 Apr 02

Journal article

African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and infection. By engineering CRISPR-Cas systems to target nine specific loci within the ASFV genome, we observed a substantial reduction in viral replication in vitro. This reduction was achieved through the concerted action of both Type II and Type...


Sendai virus persistence questions the transient naive reprogramming method for iPSC generation

Published On 2024 Apr 01

Journal article

Since the revolutionary discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka, the comparison between iPSCs and embryonic stem cells (ESCs) has revealed significant differences in their epigenetic states and developmental potential. A recent compelling study published in Nature by Buckberry et al.¹ demonstrated that a transient-naive-treatment (TNT) could facilitate epigenetic reprogramming and improve the developmental potential of human iPSCs (hiPSCs). However, the study...