Director, NHGRI Center for Excellence in Genomic Science
Robert Winthrop Professor of Genetics, Harvard Medical School
Professor of Health Sciences and Technology, Harvard and MIT
Founding Core Faculty and Lead, Wyss Institute, Harvard University
Dr. Church is Professor of Genetics at Harvard Medical
School and Professor of Health Sciences and Technology at Harvard and the
Massachusetts Institute of Technology (MIT), a founding member of the Wyss
Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic,
environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN
Projects, and Director of the National Institutes of Health Center for
Excellence in Genomic Science.
Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.
He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.
Director, NHGRI Center for Excellence in Genomic Science
Robert Winthrop Professor of Genetics, Harvard Medical School
Professor of Health Sciences and Technology, Harvard and MIT
Founding Core Faculty and Lead, Wyss Institute, Harvard University
Dr. Church is Professor of Genetics at Harvard Medical
School and Professor of Health Sciences and Technology at Harvard and the
Massachusetts Institute of Technology (MIT), a founding member of the Wyss
Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic,
environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN
Projects, and Director of the National Institutes of Health Center for
Excellence in Genomic Science.
Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.
He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.
Journal article
While many computational tools exist for designing CRISPR-Cas experiments, there is a need for a centralized resource that combines individual tools to predict the most efficient genome editing strategy for a given application. To fill this gap, we develop EditABLE (EditABLE-app.stanford.edu), an online resource that provides optimal CRISPR editors and guide RNAs based on user provided sequence data with functionalities for base editing, prime editing, and integrase-mediated editing. We...
Journal article
Direct measurement of interleukin-33 (IL-33) in biological systems is critical for understanding its role in inflammatory diseases. In this work, we have developed a platform for the discovery and optimisation of fluorogenic biosensors that are built from scFv protein scaffolds. Our approach combined site-specific fluorophore labelling and deep-learning protein design to identify BS-7 as a biosensor for wash-free detection of human IL-33 in cell supernatants.