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George Church

Ph.D.

Director, NHGRI Center for Excellence in Genomic Science

Robert Winthrop Professor of Genetics, Harvard Medical School

Professor of Health Sciences and Technology, Harvard and MIT

Founding Core Faculty and Lead, Wyss Institute, Harvard University

Dr. Church  is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT), a founding member of the Wyss Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic, environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN Projects, and Director of the National Institutes of Health Center for Excellence in Genomic Science. 

Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.

He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.

George Church

Ph.D.

Director, NHGRI Center for Excellence in Genomic Science

Robert Winthrop Professor of Genetics, Harvard Medical School

Professor of Health Sciences and Technology, Harvard and MIT

Founding Core Faculty and Lead, Wyss Institute, Harvard University

Dr. Church  is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT), a founding member of the Wyss Institute, and Director of PersonalGenomes.org, the world’s only open-access information on human genomic, environmental, and trait data. Dr. Church is Director of IARPA & NIH BRAIN Projects, and Director of the National Institutes of Health Center for Excellence in Genomic Science. 

Dr. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. He has co-authored more than 590 papers and 155 patent publications, and one book, “Regenesis”.

He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute, the Time 100, and election to the National Academy of Sciences and Engineering.

Recent Publications

Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging

Published On 2026 Jun 12

Journal article

Hematopoietic stem and progenitor cell (HSPC) aging contributes to immune dysfunction and age-associated disease, but its regulatory mechanisms remain unclear. Here, we present the largest single-cell multiome atlas of human circulating HSPCs to date, with >380,000 paired RNA and ATAC profiles across 77 donors. Beyond recapitulating established hallmarks of HSPC aging, we reconstructed a high-resolution gene regulatory network and identified a global rewiring in which stress-response and myeloid...


Programmable Nucleic Acid Sensing in Human Cells Using Circularizable ssDNA

Published On 2026 Jun 05

Journal article

Programmable technologies that sense nucleic acid signatures in living cells and trigger cellular functions hold promise for biotechnology and medicine. Here, we develop SONAR (Sensing Of Nucleic acids using ASOs and Reverse-transcriptases), a platform that detects target DNA and RNA sequences and triggers controlled gene expression in human cells. SONAR operates through circularizable single-stranded DNA (ssDNA) sensors that, upon hybridization with complementary DNA or reverse-transcribed RNA,...