Clinical Director, Division of Cancer Genetics and Prevention
Senior Physician, Dana-Farber Cancer Institute
Assistant Professor of Medicine, Harvard Medical School
Huma Q. Rana, MD, MPH is the Clinical Director
of the Division of Cancer Genetics and Prevention at Dana-Farber Cancer
Institute, and Assistant Professor of Medicine at Harvard Medical School. At
Dana-Farber and its affiliates and satellites, Dr. Rana oversees the medical
management and the clinical operations that provide care to individuals with
rare genetic susceptibilities to cancer.
In addition to her clinical work, Dr. Rana leads
multiple clinical research projects focused on developing cancer prevention and
screening for those with hereditary cancer risk, and novel approaches to
improving access to cancer genetics services.
Dr. Rana received her medical degree from the Rutgers
Robert Wood Johnson Medical School, completed her residencies in Internal
Medicine and Clinical Genetics at the Icahn School of Medicine at Mount Sinai,
and received her MPH from the Harvard T.H. Chan School of Public Health. She has been a member of the Dana-Farber
faculty since 2012.
Clinical Director, Division of Cancer Genetics and Prevention
Senior Physician, Dana-Farber Cancer Institute
Assistant Professor of Medicine, Harvard Medical School
Huma Q. Rana, MD, MPH is the Clinical Director
of the Division of Cancer Genetics and Prevention at Dana-Farber Cancer
Institute, and Assistant Professor of Medicine at Harvard Medical School. At
Dana-Farber and its affiliates and satellites, Dr. Rana oversees the medical
management and the clinical operations that provide care to individuals with
rare genetic susceptibilities to cancer.
In addition to her clinical work, Dr. Rana leads
multiple clinical research projects focused on developing cancer prevention and
screening for those with hereditary cancer risk, and novel approaches to
improving access to cancer genetics services.
Dr. Rana received her medical degree from the Rutgers
Robert Wood Johnson Medical School, completed her residencies in Internal
Medicine and Clinical Genetics at the Icahn School of Medicine at Mount Sinai,
and received her MPH from the Harvard T.H. Chan School of Public Health. She has been a member of the Dana-Farber
faculty since 2012.
Journal article
CONCLUSIONS AND RELEVANCE: In this cohort study, individuals with 2 LR variants in CHEK2 had a cancer phenotype similar to those with a single LR variant and similar to WT controls. Individuals with 1 PV and 1 LR variant may have a more penetrant cancer phenotype than individuals with a single PV. Future studies focused on CHEK2 LR variants will aid in better understanding whether these variants are genetic modifiers associated with cancer risk.
Journal article
CONCLUSION: This case series demonstrates that a PCP champion eConsult model can feasibly triage and respond to genetics questions with PCP-relevant content and yield high provider satisfaction. Such a model warrants further evaluation as an addition to the genetic services of health care systems.