Assistant Professor of Genetics, Harvard Medical School
Director, Harvard Medical School Genetics Training Program Course
Attending Physician in Clinical Genetics, Boston Children’s Hospital
Director, Pharmacogenomics Service
Dr. Picker graduated in Medicine from
Aberdeen University in Scotland. He followed this with training in Pediatrics
and a PhD in Molecular Biology (Agriculture), both carried out in Newcastle
upon Tyne, England. Following this he undertook clinical genetics and child and
adolescent psychiatry training at Boston Children’s Hospital where he has
stayed on as faculty.
He is focused on bringing personalized medicine into the mainstream. His research is focused on application of genomics with special reference to behavioral disorders.
At BCH, he is focused on development of
personalized medicine through leading the education of trainees (as director of
the Advanced Human Genetics Course at Harvard Medical School) as well as
directly via the co-founding and co- directorship of the BCH Pharmacogenomic
clinic, the first dedicated precision medicine clinical initiative at BCH. In
addition to clinical care, this clinic plays a central role in training and
support within and beyond the hospital.
Assistant Professor of Genetics, Harvard Medical School
Director, Harvard Medical School Genetics Training Program Course
Attending Physician in Clinical Genetics, Boston Children’s Hospital
Director, Pharmacogenomics Service
Dr. Picker graduated in Medicine from
Aberdeen University in Scotland. He followed this with training in Pediatrics
and a PhD in Molecular Biology (Agriculture), both carried out in Newcastle
upon Tyne, England. Following this he undertook clinical genetics and child and
adolescent psychiatry training at Boston Children’s Hospital where he has
stayed on as faculty.
He is focused on bringing personalized medicine into the mainstream. His research is focused on application of genomics with special reference to behavioral disorders.
At BCH, he is focused on development of
personalized medicine through leading the education of trainees (as director of
the Advanced Human Genetics Course at Harvard Medical School) as well as
directly via the co-founding and co- directorship of the BCH Pharmacogenomic
clinic, the first dedicated precision medicine clinical initiative at BCH. In
addition to clinical care, this clinic plays a central role in training and
support within and beyond the hospital.
Journal article
Genomic reanalysis can identify causative variants for rare diseases as patient phenotypes evolve and gene-disease knowledge expands. Despite its diagnostic value, routine reanalysis is limited by clinician capacity, lack of patient follow-up, data silos, cost, and lack of availability of clinical data to testing laboratories that are not obligated to conduct reanalysis. The Children's Rare Disease Collaborative at Boston Children's Hospital (BCH) has integrated genomic and phenotypic data from...
Journal article
CONCLUSION: The ID-behavioral comorbidity associations reported here could help in the identification and management of problematic behaviors in individuals with FXS and other ID-associated disorders.