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RESEARCH

To address this concern, we aim to design a comprehensive screen test for national population genetic screening. This will include ~400-450 genes associated with genetic diseases found at an increased frequency in the different populations in the Middle East and will identify pathogenic variants. As a result, there is an opportunity to use screening to identify these otherwise healthy individuals and consider implementing clinical interventions early, thereby reducing the risk of undesirable outcomes caused by missed or late diagnoses. In addition, because many of these disorders are inherited in autosomal recessive or X-linked manners, patients may be at risk of passing on a genetic disorder to their children without knowing it.