Publications | International Center for Genetic Disease at Harvard Medical School

Population-specific causal disease effect sizes in functionally important regions impacted by selection.

Authors :Shi H , Gazal S , Kanai M , Koch EM , Schoech AP , Siewert KM , Kim SS , Luo Y , Amariuta T , Huang H , Okada Y , Raychaudhuri S , Sunyaev SR , Price AL

Published On :2021 Feb 17

Journal Article Research Support, N.I.H., Extramural

The seroprevalence and kinetics of IgM and IgG in the progression of COVID-19.

Authors :Qin X , Shen J , Dai E , Li H , Tang G , Zhang L , Hou X , Lu M , Wu X , Duan S , Zhang J , Tsoi MF , Jiang P , Li Y

Published On :2021 Feb 17

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis.

Authors :Haisma SM , Weersma RK , Joosse ME , de Koning BAE , de Meij T , Koot BGP , Wolters V , Norbruis O , Daly MJ , Stevens C , Xavier RJ , Koskela J , Rivas MA , Visschedijk MC , Verkade HJ , Barbieri R , Jansen DBH , Festen EAM , van Rheenen PF , van Diemen CC

Published On :2021 May

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Association of Parental Consanguinity With Papillary Thyroid Carcinoma: A Case-Control Study.

Authors :Zayed AA , Amarin JZ , Al-Ani AT , Altell TL , Abdelhamid SS , Qirem MM , Fahmawi SM , Elshebli SM , Hamo KM , Zaghlol LY , Tierney ME , Zayed JA , Haghighi A

Published On :2021 Jun 16

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases.

Authors :Kobren SN , Baldridge D , Velinder M , Krier JB , LeBlanc K , Esteves C , Pusey BN , Züchner S , Blue E , Lee H , Huang A , Bastarache L , Bican A , Cogan J , Marwaha S , Alkelai A , Murdock DR , Liu P , Wegner DJ , Paul AJ , Undiagnosed Diseases Network , Sunyaev SR , Kohane IS

Published On :2021 Jun

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

MIPP-Seq: ultra-sensitive rapid detection and validation of low-frequency mosaic mutations.

Authors :Doan RN , Miller MB , Kim SN , Rodin RE , Ganz J , Bizzotto S , Morillo KS , Huang AY , Digumarthy R , Zemmel Z , Walsh CA

Published On :2021 Feb 12

Journal Article Validation Study

Clinical Syndromic Phenotypes and the Potential Role of Genetics in Pulmonary Vein Stenosis.

Authors :Zaidi AH , Yamada JM , Miller DT , McEnaney K , Ireland C , Roberts AE , Gauvreau K , Jenkins KJ , Chen MH

Published On :2021 Feb 10

Journal Article

Is X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy a congenital disorder of glycosylation?

Authors :Berry GT , Freeze HH , Morava E

Published On :2021 Feb

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Deep diversification of an AAV capsid protein by machine learning.

Authors :Bryant DH , Bashir A , Sinai S , Jain NK , Ogden PJ , Riley PF , Church GM , Colwell LJ , Kelsic ED

Published On :2021 Jun

Letter Research Support, Non-U.S. Gov't

Electrochemically dealloyed nanoporous Fe(40)Ni(20)Co(20)P(15)C(5) metallic glass for efficient and stable electrocatalytic hydrogen and oxygen generation.

Authors :Aneeshkumar KS , Tseng JC , Liu X , Tian J , Diao D , Shen J

Published On :2021 Feb 10

Journal Article

Preoperative prediction of axillary sentinel lymph node burden with multiparametric MRI-based radiomics nomogram in early-stage breast cancer.

Authors :Zhang X , Yang Z , Cui W , Zheng C , Li H , Li Y , Lu L , Mao J , Zeng W , Yang X , Zheng J , Shen J

Published On :2021 Aug

Journal Article

Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.

Authors :Chan YK , Wang SK , Chu CJ , Copland DA , Letizia AJ , Costa Verdera H , Chiang JJ , Sethi M , Wang MK , Neidermyer WJ Jr , Chan Y , Lim ET , Graveline AR , Sanchez M , Boyd RF , Vihtelic TS , Inciong RGCO , Slain JM , Alphonse PJ , Xue Y , Robinson-McCarthy LR , Tam JM , Jabbar MH , Sahu B , Adeniran JF , Muhuri M , Tai PWL , Xie J , Krause TB , Vernet A , Pezone M , Xiao R , Liu T , Wang W , Kaplan HJ , Gao G , Dick AD , Mingozzi F , McCall MA , Cepko CL , Church GM

Published On :2021 Feb 10

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

High rates of de novo malignancy compromise post-heart transplantation survival.

Authors :Giuliano K , Canner JK , Etchill E , Suarez-Pierre A , Choi CW , Higgins RSD , Hsu S , Sharma K , Kilic A

Published On :2021 Apr

Journal Article

Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency.

Authors :Sun B , Yang X , Hou F , Yu X , Wang Q , Oh HS , Raja P , Pesola JM , Vanni EAH , McCarron S , Morris-Love J , Ng AHM , Church GM , Knipe DM , Coen DM , Pan D

Published On :2021 May

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency.

Authors :Ward T , Tai W , Morton S , Impens F , Van Damme P , Van Haver D , Timmerman E , Venturini G , Zhang K , Jang MY , Willcox JAL , Haghighi A , Gelb BD , Chung WK , Goldmuntz E , Porter GA Jr , Lifton RP , Brueckner M , Yost HJ , Bruneau BG , Gorham J , Kim Y , Pereira A , Homsy J , Benson CC , DePalma SR , Varland S , Chen CS , Arnesen T , Gevaert K , Seidman C , Seidman JG

Published On :2021 Apr 16

Clinical Trial Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't