Publications | International Center for Genetic Disease at Harvard Medical School

A missense variant in SLC39A8 confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.

Authors :Nakata T , Creasey EA , Kadoki M , Lin H , Selig MK , Yao J , Lefkovith A , Daly MJ , Graham DB , Xavier RJ

Published On :2020 Nov 17

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment.

Authors :Xu L , Qu C , Qu C , Shen J , Song H , Li Y , Li T , Zheng J , Zhang J

Published On :2020 Nov 20

Journal Article Research Support, Non-U.S. Gov't

The Evolving Role of Disulfiram in Radiobiology and the Treatment of Breast Cancer.

Authors :Wang R , Shen J , Yan H , Gao X , Dong T , Wang P , Zhou J

Published On :2020

Journal Article Review

Repeated delivery of chlorhexidine chips for the treatment of peri-implantitis: A multicenter, randomized, comparative clinical trial.

Authors :Machtei EE , Romanos G , Kang P , Travan S , Schmidt S , Papathanasiou E , Tatarakis N , Tandlich M , Liberman LH , Horwitz J , Bassir SH , Myneni S , Shiau HJ , Shapira L , Donos N , Papas A , Meyle J , Giannobile WV , Papapanou PN , Kim DM

Published On :2021 Jan

Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease.

Authors :Ruotsalainen SE , Partanen JJ , Cichonska A , Lin J , Benner C , Surakka I , FinnGen , Reeve MP , Palta P , Salmi M , Jalkanen S , Ahola-Olli A , Palotie A , Salomaa V , Daly MJ , Pirinen M , Ripatti S , Koskela J

Published On :2021 Feb

Journal Article Research Support, Non-U.S. Gov't

Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.

Authors :Iqbal S , Pérez-Palma E , Jespersen JB , May P , Hoksza D , Heyne HO , Ahmed SS , Rifat ZT , Rahman MS , Lage K , Palotie A , Cottrell JR , Wagner FF , Daly MJ , Campbell AJ , Lal D

Published On :2020 Nov 10

Journal Article Research Support, Non-U.S. Gov't

A Phenomenological Study on New Care Needs of Maslow's Need-Hierarchy Among Disabled Residents at Nursing Homes in Modern Chinese Society.

Authors :Shen J , Xiao LD , Liu Y , Zhang H , Wu L

Published On :2021 Sep

Journal Article Research Support, Non-U.S. Gov't

Development of a susceptibility gene based novel predictive model for the diagnosis of ulcerative colitis using random forest and artificial neural network.

Authors :Li H , Lai L , Shen J

Published On :2020 Oct 24

Journal Article Research Support, Non-U.S. Gov't

Prevalence and Effect of Genetic Risk of Thromboembolic Disease in Inflammatory Bowel Disease.

Authors :Naito T , Botwin GJ , Haritunians T , Li D , Yang S , Khrom M , Braun J , NIDDK IBD Genetics Consortium , Abbou L , Mengesha E , Stevens C , Masamune A , Daly M , McGovern DPB

Published On :2021 Feb

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Evaluation of Extracorporeal Membrane Oxygenation Therapy as a Bridging Method.

Authors :Lui C , Fraser CD 3rd , Suarez-Pierre A , Zhou X , Higgins RSD , Zehr KJ , Choi CW , Kilic A

Published On :2021 Jul

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome.

Authors :Dyment DA , O'Donnell-Luria A , Agrawal PB , Coban Akdemir Z , Aleck KA , Antaki D , Al Sharhan H , Au PB , Aydin H , Beggs AH , Bilguvar K , Boerwinkle E , Brand H , Brownstein CA , Buyske S , Chodirker B , Choi J , Chudley AE , Clericuzio CL , Cox GF , Curry C , de Boer E , de Vries BBA , Dunn K , Dutmer CM , England EM , Fahrner JA , Geckinli BB , Genetti CA , Gezdirici A , Gibson WT , Gleeson JG , Greenberg CR , Hall A , Hamosh A , Hartley T , Jhangiani SN , Karaca E , Kernohan K , Lauzon JL , Lewis MES , Lowry RB , López-Giráldez F , Matise TC , McEvoy-Venneri J , McInnes B , Mhanni A , Garcia Minaur S , Moilanen J , Nguyen A , Nowaczyk MJM , Posey JE , Õunap K , Pehlivan D , Pajusalu S , Penney LS , Poterba T , Prontera P , Doriqui MJR , Sawyer SL , Sobreira N , Stanley V , Torun D , Wargowski D , Witmer PD , Wong I , Xing J , Zaki MS , Zhang Y , Care4Rare Consortium , Centers for Mendelian Genomics , Boycott KM , Bamshad MJ , Nickerson DA , Blue EE , Innes AM

Published On :2021 Jan

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing.

Authors :Angrist M , Barrangou R , Baylis F , Brokowski C , Burgio G , Caplan A , Chapman CR , Church GM , Cook-Deegan R , Cwik B , Doudna JA , Evans JH , Greely HT , Hercher L , Hurlbut JB , Hynes RO , Ishii T , Kiani S , Lee LH , Levrier G , Liu DR , Lunshof JE , Macintosh KL , Mathews DJH , Meslin EM , Mills PHR , Montoliu L , Musunuru K , Nicol D , O'Neill H , Qiu R , Ranisch R , Sherkow JS , Soni S , Terry S , Topol E , Williamson R , Zhang F , Davies K

Published On :2020 Oct

Journal Article

Mentorship at a distance.

Authors :Rankin NA , Gröschel MI , Farhat MR

Published On :2020 Oct 23

Journal Article

Peptide-Modified Nanoparticles for Tumor Targeting and Molecular Imaging.

Authors :Lu L , Zhang Q , Wang Z , Gao L , Shen J

Published On :2021

Journal Article Review

A predictive signature for oxaliplatin and 5-fluorouracil based chemotherapy in locally advanced gastric cancer.

Authors :Wang Q , Liu X , Chen C , Chen J , Xu B , Chen L , Zhou J , Huang Y , Chen W , Teng R , Zhao W , Jin L , Shen J , Shen J , Yen Y , Wang L

Published On :2021 Jan

Journal Article