Publications | International Center for Genetic Disease at Harvard Medical School

The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.

Authors :Lin SY , Vollrath MA , Mangosing S , Shen J , Cardenas E , Corey DP

Published On :2016 Feb 15

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain.

Authors :Zhong XM , Zhang F , Yang M , Wen XH , Zhang X , Duan XH , Shen J

Published On :2015

Journal Article Research Support, Non-U.S. Gov't

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.

Authors :Palamara PF , Francioli LC , Wilton PR , Genovese G , Gusev A , Finucane HK , Sankararaman S , Genome of the Netherlands Consortium , Sunyaev SR , de Bakker PI , Wakeley J , Pe'er I , Price AL

Published On :2015 Dec 3

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Safeguarding CRISPR-Cas9 gene drives in yeast.

Authors :DiCarlo JE , Chavez A , Dietz SL , Esvelt KM , Church GM

Published On :2015 Dec

Journal Article

Early acetabular cartilage degeneration in a rabbit model of developmental dysplasia of the hip.

Authors :Zhang X , Meng Q , Ma R , Chen G , Cheng L , Shen J

Published On :2015

Journal Article

Efficient Reassignment of a Frequent Serine Codon in Wild-Type Escherichia coli.

Authors :Ho JM , Reynolds NM , Rivera K , Connolly M , Guo LT , Ling J , Pappin DJ , Church GM , Söll D

Published On :2016 Feb 19

Journal Article Research Support, N.I.H., Extramural

Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.

Authors :Antman EM , Benjamin EJ , Harrington RA , Houser SR , Peterson ED , Bauman MA , Brown N , Bufalino V , Califf RM , Creager MA , Daugherty A , Demets DL , Dennis BP , Ebadollahi S , Jessup M , Lauer MS , Lo B , MacRae CA , McConnell MV , McCray AT , Mello MM , Mueller E , Newburger JW , Okun S , Packer M , Philippakis A , Ping P , Prasoon P , Roger VL , Singer S , Temple R , Turner MB , Vigilante K , Warner J , Wayte P , American Heart Association Data Sharing Summit Attendees

Published On :2015 Nov 5

Conference Proceedings

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Authors :Prel A , Caval V , Gayon R , Ravassard P , Duthoit C , Payen E , Maouche-Chretien L , Creneguy A , Nguyen TH , Martin N , Piver E , Sevrain R , Lamouroux L , Leboulch P , Deschaseaux F , Bouillé P , Sensébé L , Pagès JC

Published On :2015

Journal Article

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions.

Authors :Kazanov MD , Roberts SA , Polak P , Stamatoyannopoulos J , Klimczak LJ , Gordenin DA , Sunyaev SR

Published On :2015 Nov 10

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma.

Authors :Zhuang PY , Wang JD , Tang ZH , Zhou XP , Quan ZW , Liu YB , Shen J

Published On :2015 Nov 2

Journal Article Research Support, Non-U.S. Gov't

Spectral fitting using basis set modified by measured B0 field distribution.

Authors :Li N , An L , Shen J

Published On :2015 Dec

Journal Article Research Support, N.I.H., Intramural

An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood.

Authors :Cassa CA , Smith SE , Docken W , Hoffman E , McLaughlin H , Chun S , Leshchiner I , Miraoui H , Raychaudhuri S , Frank NY , Wilson BJ , Sunyaev SR , Maas RL , Brigham Genomic Medicine , Vuzman D

Published On :2016 Mar

Case Reports Letter Research Support, N.I.H., Extramural

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.

Authors :Cleynen I , Boucher G , Jostins L , Schumm LP , Zeissig S , Ahmad T , Andersen V , Andrews JM , Annese V , Brand S , Brant SR , Cho JH , Daly MJ , Dubinsky M , Duerr RH , Ferguson LR , Franke A , Gearry RB , Goyette P , Hakonarson H , Halfvarson J , Hov JR , Huang H , Kennedy NA , Kupcinskas L , Lawrance IC , Lee JC , Satsangi J , Schreiber S , Théâtre E , van der Meulen-de Jong AE , Weersma RK , Wilson DC , International Inflammatory Bowel Disease Genetics Consortium , Parkes M , Vermeire S , Rioux JD , Mansfield J , Silverberg MS , Radford-Smith G , McGovern DP , Barrett JC , Lees CW

Published On :2016 Jan 9

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Authors :Cao Z , Conway KL , Heath RJ , Rush JS , Leshchiner ES , Ramirez-Ortiz ZG , Nedelsky NB , Huang H , Ng A , Gardet A , Cheng SC , Shamji AF , Rioux JD , Wijmenga C , Netea MG , Means TK , Daly MJ , Xavier RJ

Published On :2015 Oct 20

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing.

Authors :Tsioris K , Gupta NT , Ogunniyi AO , Zimnisky RM , Qian F , Yao Y , Wang X , Stern JN , Chari R , Briggs AW , Clouser CR , Vigneault F , Church GM , Garcia MN , Murray KO , Montgomery RR , Kleinstein SH , Love JC

Published On :2015 Dec

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't