Publications | International Center for Genetic Disease at Harvard Medical School

Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin.

Authors :Haynes SW , Gao X , Tang Y , Walsh CT

Published On :2013 Apr 19

Journal Article Research Support, N.I.H., Extramural Validation Study

Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory bowel disease.

Authors :Shen J , Qiao YQ , Ran ZH , Wang TR

Published On :2013

Journal Article Research Support, Non-U.S. Gov't

An analysis and validation pipeline for large-scale RNAi-based screens.

Authors :Plank M , Hu G , Silva AS , Wood SH , Hesketh EE , Janssens G , Macedo A , de Magalhães JP , Church GM

Published On :2013

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Late-onset radiation-induced optic neuropathy after radiotherapy for nasopharyngeal carcinoma.

Authors :Zhao Z , Lan Y , Bai S , Shen J , Xiao S , Lv R , Zhang B , Tao E , Liu J

Published On :2013 May

Journal Article Research Support, Non-U.S. Gov't

Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.

Authors :Parker JB , Walsh CT

Published On :2013 Feb 5

Journal Article Research Support, N.I.H., Extramural

Predicting functional effect of human missense mutations using PolyPhen-2.

Authors :Adzhubei I , Jordan DM , Sunyaev SR

Published On :2013 Jan

Journal Article

Noonan syndrome.

Authors :Roberts AE , Allanson JE , Tartaglia M , Gelb BD

Published On :2013 Jan 26

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Using bacteria to determine protein kinase specificity and predict target substrates.

Authors :Chou MF , Prisic S , Lubner JM , Church GM , Husson RN , Schwartz D

Published On :2012

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

RNA-guided human genome engineering via Cas9.

Authors :Mali P , Yang L , Esvelt KM , Aach J , Guell M , DiCarlo JE , Norville JE , Church GM

Published On :2013 Feb 15

Journal Article Research Support, N.I.H., Extramural

MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment.

Authors :Quiat D , Olson EN

Published On :2013 Jan

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Hybrid coupled cluster methods based on the split virtual orbitals: barrier heights of reactions and spectroscopic constants of open-shell diatomic molecules.

Authors :Kou Z , Shen J , Xu E , Li S

Published On :2013 Jan 24

Journal Article

Schizencephaly: association with young maternal age, alcohol use, and lack of prenatal care.

Authors :Dies KA , Bodell A , Hisama FM , Guo CY , Barry B , Chang BS , Barkovich AJ , Walsh CA

Published On :2013 Feb

Journal Article Research Support, N.I.H., Extramural

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

Authors :Huyghe JR , Jackson AU , Fogarty MP , Buchkovich ML , Stančáková A , Stringham HM , Sim X , Yang L , Fuchsberger C , Cederberg H , Chines PS , Teslovich TM , Romm JM , Ling H , McMullen I , Ingersoll R , Pugh EW , Doheny KF , Neale BM , Daly MJ , Kuusisto J , Scott LJ , Kang HM , Collins FS , Abecasis GR , Watanabe RM , Boehnke M , Laakso M , Mohlke KL

Published On :2013 Feb

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.

Authors :Young TS , Dorrestein PC , Walsh CT

Published On :2012 Dec 21

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Authors :Diogo D , Kurreeman F , Stahl EA , Liao KP , Gupta N , Greenberg JD , Rivas MA , Hickey B , Flannick J , Thomson B , Guiducci C , Ripke S , Adzhubey I , Barton A , Kremer JM , Alfredsson L , Consortium of Rheumatology Researchers of North America , Rheumatoid Arthritis Consortium International , Sunyaev S , Martin J , Zhernakova A , Bowes J , Eyre S , Siminovitch KA , Gregersen PK , Worthington J , Klareskog L , Padyukov L , Raychaudhuri S , Plenge RM

Published On :2013 Jan 10

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't