Publications | International Center for Genetic Disease at Harvard Medical School

Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies.

Authors :Liu X , Walsh CT

Published On :2009 Nov 24

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Generation of functional human hepatic endoderm from human induced pluripotent stem cells.

Authors :Sullivan GJ , Hay DC , Park IH , Fletcher J , Hannoun Z , Payne CM , Dalgetty D , Black JR , Ross JA , Samuel K , Wang G , Daley GQ , Lee JH , Church GM , Forbes SJ , Iredale JP , Wilmut I

Published On :2010 Jan

Journal Article Research Support, Non-U.S. Gov't

Use of array comparative genomic hybridization for prenatal diagnosis of fetuses with sonographic anomalies and normal metaphase karyotype.

Authors :Kleeman L , Bianchi DW , Shaffer LG , Rorem E , Cowan J , Craigo SD , Tighiouart H , Wilkins-Haug LE

Published On :2009 Dec

Clinical Trial Journal Article Multicenter Study

The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.

Authors :Gómez García I , Stevenson CE , Usón I , Freel Meyers CL , Walsh CT , Lawson DM

Published On :2010 Jan 15

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation.

Authors :McGlinn E , Yekta S , Mansfield JH , Soutschek J , Bartel DP , Tabin CJ

Published On :2009 Nov 3

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

Authors :International MHC and Autoimmunity Genetics Network , Rioux JD , Goyette P , Vyse TJ , Hammarström L , Fernando MM , Green T , De Jager PL , Foisy S , Wang J , de Bakker PI , Leslie S , McVean G , Padyukov L , Alfredsson L , Annese V , Hafler DA , Pan-Hammarström Q , Matell R , Sawcer SJ , Compston AD , Cree BA , Mirel DB , Daly MJ , Behrens TW , Klareskog L , Gregersen PK , Oksenberg JR , Hauser SL

Published On :2009 Nov 3

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach.

Authors :Sobrin L , Maller JB , Neale BM , Reynolds RC , Fagerness JA , Daly MJ , Seddon JM

Published On :2010 Apr

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A suggested role for mitochondria in Noonan syndrome.

Authors :Lee I , Pecinova A , Pecina P , Neel BG , Araki T , Kucherlapati R , Roberts AE , Hüttemann M

Published On :2010 Feb

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

Authors :Matthews ML , Neumann CS , Miles LA , Grove TL , Booker SJ , Krebs C , Walsh CT , Bollinger JM Jr

Published On :2009 Oct 20

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Temporomandibular joint formation requires two distinct hedgehog-dependent steps.

Authors :Purcell P , Joo BW , Hu JK , Tran PV , Calicchio ML , O'Connell DJ , Maas RL , Tabin CJ

Published On :2009 Oct 27

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A genome-wide linkage and association scan reveals novel loci for autism.

Authors :Weiss LA , Arking DE , Gene Discovery Project of Johns Hopkins & the Autism Consortium , Daly MJ , Chakravarti A

Published On :2009 Oct 8

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.

Authors :Hollenhorst MA , Clardy J , Walsh CT

Published On :2009 Nov 3

Journal Article Research Support, N.I.H., Extramural

Identification of novel genes that mediate innate immunity using inbred mice.

Authors :Yang IV , Wade CM , Kang HM , Alper S , Rutledge H , Lackford B , Eskin E , Daly MJ , Schwartz DA

Published On :2009 Dec

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S.

Triplet repeat length bias and variation in the human transcriptome.

Authors :Molla M , Delcher A , Sunyaev S , Cantor C , Kasif S

Published On :2009 Oct 6

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Public access to genome-wide data: five views on balancing research with privacy and protection.

Authors :P3G Consortium , Church G , Heeney C , Hawkins N , de Vries J , Boddington P , Kaye J , Bobrow M , Weir B

Published On :2009 Oct

Comment Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't