Publications | International Center for Genetic Disease at Harvard Medical School

Predicting the binding preference of transcription factors to individual DNA k-mers.

Authors :Alleyne TM , Peña-Castillo L , Badis G , Talukder S , Berger MF , Gehrke AR , Philippakis AA , Bulyk ML , Morris QD , Hughes TR

Published On :2009 Apr 15

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

Authors :Shao H , Burrage LC , Sinasac DS , Hill AE , Ernest SR , O'Brien W , Courtland HW , Jepsen KJ , Kirby A , Kulbokas EJ , Daly MJ , Broman KW , Lander ES , Nadeau JH

Published On :2008 Dec 16

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The genome-wide patterns of variation expose significant substructure in a founder population.

Authors :Jakkula E , Rehnström K , Varilo T , Pietiläinen OP , Paunio T , Pedersen NL , deFaire U , Järvelin MR , Saharinen J , Freimer N , Ripatti S , Purcell S , Collins A , Daly MJ , Palotie A , Peltonen L

Published On :2008 Dec

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

Authors :Sabatti C , Service SK , Hartikainen AL , Pouta A , Ripatti S , Brodsky J , Jones CG , Zaitlen NA , Varilo T , Kaakinen M , Sovio U , Ruokonen A , Laitinen J , Jakkula E , Coin L , Hoggart C , Collins A , Turunen H , Gabriel S , Elliot P , McCarthy MI , Daly MJ , Järvelin MR , Freimer NB , Peltonen L

Published On :2009 Jan

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

How nature morphs peptide scaffolds into antibiotics.

Authors :Nolan EM , Walsh CT

Published On :2009 Jan 5

Journal Article Research Support, N.I.H., Extramural Review

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

Authors :Choy E , Yelensky R , Bonakdar S , Plenge RM , Saxena R , De Jager PL , Shaw SY , Wolfish CS , Slavik JM , Cotsapas C , Rivas M , Dermitzakis ET , Cahir-McFarland E , Kieff E , Hafler D , Daly MJ , Altshuler D

Published On :2008 Nov

Journal Article Research Support, Non-U.S. Gov't

Hypermutable non-synonymous sites are under stronger negative selection.

Authors :Schmidt S , Gerasimova A , Kondrashov FA , Adzhubei IA , Adzuhbei IA , Kondrashov AS , Sunyaev S

Published On :2008 Nov

Journal Article Research Support, N.I.H., Extramural

The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction.

Authors :Ryan KS , Chakraborty S , Howard-Jones AR , Walsh CT , Ballou DP , Drennan CL

Published On :2008 Dec 23

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

[Evaluation of correlation between pulmonary function testing and high resolution computed tomography in pulmonary alveolar proteinosis].

Authors :Chen QL , Shen J , Gao Y , Guan YB , An JY , Zheng JP

Published On :2008 Jul

Journal Article

Diversifying selective pressure on influenza B virus hemagglutinin.

Authors :Shen J , Kirk BD , Ma J , Wang Q

Published On :2009 Jan

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

On the level: IRGM gene function is all about expression.

Authors :Huett A , McCarroll SA , Daly MJ , Xavier RJ

Published On :2009 Jan

Journal Article

Achieving bilateral symmetry during vertebrate limb development.

Authors :Allard P , Tabin CJ

Published On :2009 Jun

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.

Authors :Alazami AM , Al-Saif A , Al-Semari A , Bohlega S , Zlitni S , Alzahrani F , Bavi P , Kaya N , Colak D , Khalak H , Baltus A , Peterlin B , Danda S , Bhatia KP , Schneider SA , Sakati N , Walsh CA , Al-Mohanna F , Meyer B , Alkuraya FS

Published On :2008 Dec

Journal Article Research Support, Non-U.S. Gov't

Bilateral frontoparietal polymicrogyria, Lennox-Gastaut syndrome, and GPR56 gene mutations.

Authors :Parrini E , Ferrari AR , Dorn T , Walsh CA , Guerrini R

Published On :2009 Jun

Journal Article Research Support, Non-U.S. Gov't

The unexplored potential of the pentose phosphate pathway in health and disease.

Authors :Berry GT

Published On :2008 Dec

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