Publications | International Center for Genetic Disease at Harvard Medical School

A Multifunctional Nanodrug Increases the Therapeutic Sensitivity of Lenvatinib to Hepatocellular Carcinoma by Inhibiting the Stemness of Hepatic Cancer Stem Cells.

Authors :Yang X , Zhang Q , Li D , Hu L , Wang Y , Yan X , Li Y , Wang Y , Zhang F , Shen J

Published On :2024 Nov

Journal Article

Healing sequelae following tooth extraction and dental implant placement in an aged, ovariectomy model.

Authors :Latimer JM , Maekawa S , Shiba T , Fretwurst T , Chen M , Larsson L , Sugai JV , Kostenuik P , Mitlak B , Lanske B , Giannobile WV

Published On :2024 Oct

Journal Article

Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria.

Authors :Bergquist T , Stenton SL , Nadeau EAW , Byrne AB , Greenblatt MS , Harrison SM , Tavtigian SV , O'Donnell-Luria A , Biesecker LG , Radivojac P , Brenner SE , Pejaver V , ClinGen Sequence Variant Interpretation Working Group

Published On :2024 Sep 21

Journal Article

Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

Authors :Marreddy RKR , Phelps GA , Churion K , Picker J , Powell R , Cherian PT , Bowling JJ , Stephan CC , Lee RE , Hurdle JG

Published On :2024 Nov

Journal Article

Comprehensive Investigation into the Impact of Degradation of Recycled Polyethylene and Recycled Polypropylene on the Thermo-Mechanical Characteristics and Thermal Stability of Blends.

Authors :Zhang W , Shen J , Guo X , Wang K , Jia J , Zhao J , Zhang J

Published On :2024 Sep 22

Journal Article

Leaving no patient behind! Expert recommendation in the use of innovative technologies for diagnosing rare diseases.

Authors :van Karnebeek CDM , O'Donnell-Luria A , Baynam G , Baudot A , Groza T , Jans JJM , Lassmann T , Letinturier MCV , Montgomery SB , Robinson PN , Sansen S , Mehrian-Shai R , Steward C , Kosaki K , Durao P , Sadikovic B

Published On :2024 Sep 27

Journal Article Review

Towards geospatially-resolved public-health surveillance via wastewater sequencing.

Authors :Tierney BT , Foox J , Ryon KA , Butler D , Damle N , Young BG , Mozsary C , Babler KM , Yin X , Carattini Y , Andrews D , Lucaci AG , Solle NS , Kumar N , Shukla B , Vidović D , Currall B , Williams SL , Schürer SC , Stevenson M , Amirali A , Beaver CC , Kobetz E , Boone MM , Reding B , Laine J , Comerford S , Lamar WE , Tallon JJ Jr , Wain Hirschberg J , Proszynski J , Al Ghalith G , Can Kurt K , Sharkey ME , Church GM , Grills GS , Solo-Gabriele HM , Mason CE

Published On :2024 Sep 27

Journal Article

The Exponential Shapeshifting Response of N-Vinylcaprolactam Hydrogel Bilayers Due to Temperature Change for Potential Minimally Invasive Surgery.

Authors :Tie BSH , Daly M , Zhuo S , Halligan E , Keane G , Geever J , Geever L

Published On :2024 Aug 24

Journal Article

The association between preserved ratio impaired spirometry and adverse outcomes of depression and anxiety: evidence from the UK Biobank.

Authors :Yang K , Wang L , Shen J , Chen S , Liu Y , Chen R

Published On :2024 Sep 26

Journal Article

Autochthonous Human Babesia divergens Infection, England.

Authors :Zabala GA , Lever R , Chan XH , Bristowe H , Kilbride E , Richards D , Daly M , Brown M , Johnson N , Nabarro LE , Esmail H , Godbole G , Chiodini PL

Published On :2024 Oct

Journal Article

The role of double heterozygotes of SLC3A1 and SLC7A9 in the prevalence of cystine stones.

Authors :Wilfred Wu CH , Patel I , Lovrenert K , Eisner B , Meeks N , Chun-Hui Tsai A , Baum M , Berry G , Schumacher FR

Published On :2025 Jan

Journal Article

Structural brain preservation: a potential bridge to future medical technologies.

Authors :McKenzie AT , Zeleznikow-Johnston A , Sparks JS , Nnadi O , Smart J , Wiley K , Cerullo MA , de Wolf A , Minerva F , Risco R , Church GM , de Magalhães JP , Kendziorra EF

Published On :2024

Journal Article

Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks.

Authors :German J , Cordioli M , Tozzo V , Urbut S , Arumäe K , Smit RAJ , Lee J , Li JH , Janucik A , Ding Y , Akinkuolie A , Heyne H , Eoli A , Saad C , Al-Sarraj Y , Abdel-Latif R , Mohammed S , Hail MA , Barry A , Wang Z , Estonian Biobank research team , Cajuso T , Corbetta A , Natarajan P , Ripatti S , Philippakis A , Szczerbinski L , Pasaniuc B , Kutalik Z , Mbarek H , Loos RJF , Vainik U , Ganna A

Published On :2025 Jan 8

Journal Article

Gene identification for ocular congenital cranial motor neuron disorders using human sequencing, zebrafish screening, and protein binding microarrays.

Authors :Jurgens JA , Matos Ruiz PM , King J , Foster EE , Berube L , Chan WM , Barry BJ , Jeong R , Rothman E , Whitman MC , MacKinnon S , Rivera-Quiles C , Pratt BM , Easterbrooks T , Mensching FM , Di Gioia SA , Pais L , England EM , de Berardinis T , Magli A , Koc F , Asakawa K , Kawakami K , O'Donnell-Luria A , Hunter DG , Robson CD , Bulyk ML , Engle EC

Published On :2024 Sep 15

Journal Article

Prenatal Ultrasonographic Features Associated With ARSL and X-Linked Chondrodysplasia Punctata 1 (CDPX1): Literature Review and Case Series.

Authors :Broeren E , Stover S , Bennett K , Giordano J , Galloway S , Lauzon J , Rust L , Suerink M , van Haeringen A , Australian Genomic Autopsy Study Team , Reimers R

Published On :2024 Dec

Journal Article