Publications | International Center for Genetic Disease at Harvard Medical School

A Novel Empirical Autoinduction Model to Characterize the Population Pharmacokinetics and Recommend Dose for Repotrectinib in Adult and Adolescents With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements.

Authors :Du S , Hu Z , Shen J , Hamuro L , Lam J , Lu M , Zhu L , Roy A , Kondic A

Published On :2025 Jul

Journal Article

Regulatable C-X-C chemokine receptor type 4 in iPSC-derived NK cells improves bone marrow chemotaxis and targeting resident tumor.

Authors :He X , Wang L , Zeng W , Wang Y , Chen N , Yang P , Ti A , Zhang Q , Shao Y , Wang M , Huang Z , Zhang X , Xu M , Liang L , Wang X , Ding X , Zhu T , Zhang P , Pan Z , Yang F , Zhou Y , Mo G , Hu J , Yue Y , Hu J , Deng Y , Ho T , Church GM , Hu Y , Huang H , Yang L

Published On :2025 Jul

Journal Article

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity.

Authors :Heng TH , Walter K , Huang QQ , Karjalainen J , Daly MJ , Heyne HO , FinnGen , Malawsky DS , Kalantzis G , Genes & Health Research Team , Finer S , van Heel DA , Martin HC

Published On :2025 Jun 5

Journal Article

A call for built-in biosecurity safeguards for generative AI tools.

Authors :Wang M , Zhang Z , Bedi AS , Velasquez A , Guerra S , Lin-Gibson S , Cong L , Qu Y , Chakraborty S , Blewett M , Ma J , Xing E , Church G

Published On :2025 Jun

Letter

A Nomogram Prediction Model for Clinical Outcome of Trauma-induced Coagulopathy Patients with Severe Multiple Trauma.

Authors :Shen J , Xu F

Published On :2025 Jan-Mar

Journal Article

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.

Authors :Shao DD , Kriz AJ , Snellings DA , Zhou Z , Zhao Y , Enyenihi L , Walsh C

Published On :2025 Nov

Journal Article Review

Quality Indicators in Otolaryngology-Head and Neck Surgery: A Scoping Review.

Authors :Staibano P , Samargandy S , Cottrell J , Wang L , Au M , Gupta MK , Zhang H , Sommer DD , Walsh C , Monteiro E

Published On :2025 Jan-Dec

Journal Article

Development and psychometric validation of a patient-reported outcome measure scale for Crohn's disease anorectal stricture.

Authors :Li JR , Yang BL , Zhu ZX , Gong YX , Wang H , Gu YF , Zhang D , Xu MM , Jiang F , Kong J , Wang XP , Xu S , Wang C , Du P , Shen J , Mao R , Ke J , Tian F , Zhu WM , Zhu P

Published On :2025 May 8

Journal Article

The diagnostic performance and reader agreement of the Prostate Imaging for Recurrence Reporting system in the evaluation of local recurrence in patients with biochemically recurrent prostate cancer.

Authors :Liu X , Yang S , Deng W , Li D , Shen J

Published On :2025 Sep

Journal Article

Ni(OH)x/Ni-Catalyzed In Situ Hydrogenation and Ethanol Ethoxylation of 2-Methylfuran for Renewable Biofuel Co-Upgrading.

Authors :Shen J , Liang C , Zhang Y , Zhang X , Li H , Li Y , Xie S , Zhang ZC

Published On :2025 Jun 6

Journal Article

Low Allele Frequency Variants Identified on Germline Multi-Gene Panel Testing for Cancer Predisposition Can Suggest the Presence of Constitutional Mosaicism.

Authors :Rodriguez-Hernandez A , Polfus LM , Bychkovsky BL , Souders B , Prat A , Adamo B , Garber JE , Horton C , Rana HQ

Published On :2025 Jul 1

Journal Article

The impact of information technology applications on the quality of life of disabled older adults in nursing homes in China: a qualitative study.

Authors :Zhang H , Liao X , Liang S , Tong L , Shen J , Peng B , Wu L , Gao L , Jia Q , Ren L , Luo L , Wang Y , Zhang X

Published On :2025

Journal Article

A diverse single-stranded DNA-annealing protein library enables efficient genome editing across bacterial phyla.

Authors :Filsinger GT , Mychack A , Lyerly E , Henriksen C , Bartlett TM , Kuchwara H , Eitzinger S , Bernhardt TG , Walker S , Church GM , Wannier TM

Published On :2025 Apr 29

Journal Article

A Systematic Literature Review on Pre-exposure Prophylaxis as a Strategy for HIV Risk Reduction in the Middle East.

Authors :Chaponda M , AlHammadi AA , Alsaeed A , Ali B , Al Salman J , Alosaimi RS

Published On :2025 Mar

Journal Article Review

Machine learning-assisted prediction of clinical responses to periodontal treatment.

Authors :Feher B , de Souza Oliveira EH , Mendes Duarte P , Werdich AA , Giannobile WV , Feres M

Published On :2025 Nov

Journal Article