Publications | International Center for Genetic Disease at Harvard Medical School

Identification of an SFRP1 inhibitor as a potential therapeutic strategy for cancers using dry-wet combined drug discovery strategy.

Authors :Zhang Y , Wei R , Pan M , Qin N , Wei X , Shen J

Published On :2026 May 27

Journal Article

MoS(2) Heterojunction-Based Gas Sensor Platform Enables Real-Time Detection of Sarin at Room Temperature via Strong Adsorption and Enhanced Charge Transfer.

Authors :Shen J , Li H , Chen H , Wu G , Cui Y , Chen L , Li X , Wang H , Cao S , Zheng Y

Published On :2026 May 27

Journal Article

Exploring the impact of melatonin on cancer-related fatigue: a dose-response meta-analysis with GRADE evidence evaluation.

Authors :Etesamnia S , Nasiraie-Moghadam M , Mostafazadeh P , Jowshan MR , Roudini K , Miri SR , Jahan-Mihan A , Haghighi A , Ebrahimpour-Koujan S

Published On :2026 May 26

Journal Article

A diagnostic challenge of dual atrioventricular nodal nonreentrant tachycardia revealed by ambulatory electrocardiographic monitoring: a case report.

Authors :Ma Z , Tian J , Yuan P , Shen J

Published On :2026

Case Reports Journal Article

Exome sequencing directly implicates 68 genes in inflammatory bowel disease.

Authors :Zhu R , Zhang Q , Yuan K , Zhang R , Turvey AK , Stevens CR , Fachal L , IIBDGC Sequencing Group , Ahmad T , Bel Kok K , Bernstein CN , Bokemeyer B , Brant SR , Brooks J , Butterworth J , Cho JH , Clark K , Cummings F , Duerr RH , Ennis S , Farkkila M , Faubion WA , Foley S , Franchimont D , Franke A , Hancock L , Hart A , Hooper P , Irving P , Jarvis M , Johnston E , Karlson EW , Kemp C , Kennedy N , Kupcinskas J , Lamb C , Lees C , Lewis J , Li A , Limdi J , Loescher BS , Louis E , McCauley JL , McGovern D , McLaughlin J , Moayyedi P , Moran G , Newberry R , Oglesby A , Palotie A , Pekow J , Perez KJ , Pollok R , Prescott N , Raine T , Ramadas A , Ramakrishnan S , Sabic K , Sands B , Satsangi J , Sazonovs A , Schreiber S , Selinger C , Shedwell S , Silverberg M , Singh S , Sokol H , Steed H , Steel A , Uhlig H , Verma A , Vermeire S , Weersma R , Xavier R , Yu M , Parkes M , Rioux JD , Daly MJ , Huang H , Anderson CA

Published On :2026 May 20

Journal Article Preprint

Systematic common and rare variant association testing in 392,030 whole genomes in All of Us.

Authors :Lu W , Carroll RJ , Solomonson M , Guez J , He MK , Marten DJ , Martinez-Carrasco A , Wang Y , Dowd CS , Kanai M , Gorissen BL , Kouame AJS , Brogan J , Waxse BJ , Samarakoon R , Cook JA , Qian J , Zhou Y , Choi KW , Basford M , Lyons M , Linder JE , Stewart S , Gupta N , Schultz P , Goldstein D , Llanwarne C , Goldstein JI , Higham EGC , King DC , Palmer DS , Elenbaas JS , Rohlicek GK , He Q , Goodrich JK , All of Us Research Program Genomics Investigators , Smoller JW , Lichtenstein L , Gabriel SB , Martin AR , Karnes JH , Hebbring SJ , Daly MJ , Dutka T , Musick A , Denny JC , Zhou W , Roden DM , Neale BM , Karczewski KJ

Published On :2026 May 12

Journal Article Preprint

A genome-wide deletion map in 125,730 individuals for novel rare disease gene and variant discovery.

Authors :McGuigan A , Pagnamenta AT , Covill LE , Samson J , Camps C , Chen Y , Moitra T , Chundru K , O'Heir E , Allan K , Arno G , Broomfield A , Delatycki M , Lin S , Michaelides M , Rius R , Roscioli T , Simons C , Webster A , White SM , Wilson L , Sanders SJ , O'Donnell-Luria A , Ellingford JM , Taylor JC , Whiffin N

Published On :2026 May 15

Journal Article Preprint

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Authors :Tyrmi JS , Karjalainen J , Venkatesh SS , Benoit-Pilven C , Lemmelä SM , Brunak S , Aagaard B , Bruun MT , Erikstrup C , Ullum H , Pedersen OB , Banasik K , Sørensen E , Mikkelsen C , Schwinn M , Sturluson A , Ostrowski SR , FinnGen , Estonian Biobank research team , DBDS Genomic Consortium , Kettunen J , Nielsen HS , Nyegaard M , Westergaard D , Rafnar T , Sulem P , Stefansson K , Palta P , Laisk T , Tukiainen T , Lindgren CM , Daly M , Havulinna AS , Laivuori HM

Published On :2026 May 25

Journal Article

Genetic variants affect diurnal glucose levels throughout the day.

Authors :Sinnott-Armstrong N , Strausz S , Urpa L , Abner E , Johnson JP , Valliere J , Palumaa T , FinnGen , Estonian Biobank Research Team , VA Million Veteran Program , Palta P , Dashti HS , Chang KM , Vujkovic M , Daly M , Pritchard JK , Saxena R , Jones SE , Ollila HM

Published On :2026 May 22

Journal Article

Fatty acid oxidation and inflammatory bowel disease: Highlighting the roles of pathogenesis and treatment.

Authors :Li C , Shen J

Published On :2026 Jul

Journal Article Review

Sarsasapogenin attenuates renal ischemia-reperfusion injury by inhibiting the NF-κB pathway and NLRP3 inflammasome-mediated pyroptosis.

Authors :Yuan Q , Li Y , Shen K , Zhang R , Wang Q , Xia S , Shen J

Published On :2026 Aug 15

Journal Article

Experimental and Computational Approaches to Identify Noncoding Pathogenic Variation in Rare Disease.

Authors :Covill LE , Romo L , O'Donnell-Luria A

Published On :2026 May 21

Journal Article Review

Integrating machine learning and clinicopathological data to stratify survival risk in young women with localized breast cancer.

Authors :Xu B , Shen J , Shen J

Published On :2026

Journal Article

Inflammatory bowel disease phenotypes in diverse populations: a global comparative analysis.

Authors :Bernstein CN , Kaplan GG , Nugent Z , Ahuja V , Ananthakrishnan AN , Banerjee R , Burisch J , Chen Y , Epstein D , Forbes AJ , Gonczi L , Gu Y , Gunawan J , Hang DV , Kaibullayeva J , Kopylov U , Kotze PG , Iade B , Lakatos PL , Limsrivilai J , Liang J , Mak JWY , Ng S , Severs M , Shen J , Sood A , Yamamoto-Furusho JK , Yuan S , Wewer MD , Wu K , Windsor JW , Gearry RB , Globalization Cluster of the International Organization for the Study of IBD

Published On :2026 May 8

Journal Article Comparative Study

USP22 inhibition potentiates GPC3 chimeric antigen receptor macrophages efficacy in hepatocellular carcinoma by downregulating tumor CD24 expression.

Authors :Pan J , Pan S , Lei Y , Li J , Zhong X , Tang L , Xu S , Ling S , Lu D , Wang K , Hao S , Li L , Wu Z , Wang H , Cheng T , Shen J , Xu X , Wei Q

Published On :2026 Sep 1

Journal Article