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Yvonne I. Chekaluk

M.Sc., (MB)ASCP, PMP

Senior Program Manager

International Center for Genetic Disease

Brigham and Women’s Hospital

Harvard Medical School

After a successful career in business, she followed a long-held dream to pursue a latent interest in science. During this mid-career change, she served in a research fellowship at Harvard Medical School in cancer genetics while obtaining her graduate degree. With the loss of many loved ones to cancer, she has been passionate about her work in early diagnosis and treatment of various cancers, including pancreatic, bladder, colon, breast, and leukemia. She was pleased to contribute in technical capacities at two renowned cancer centers. She has also found herself to be passionate about the execution and oversight of scientific projects. In this capacity, she has implemented genetics efforts extending beyond her core cancer expertise: infant hearing loss, clinical genetics, and the gamut of genetic sequencing efforts typical of the Broad Institute. She has an extensive network of contacts in the genomics community, and extensive knowledge of the details of running research and clinical genomic programs

Contact Infomation

Email:

ychekaluk@bwh.harvard.edu

Yvonne I. Chekaluk

M.Sc., (MB)ASCP, PMP

Senior Program Manager

International Center for Genetic Disease

Brigham and Women’s Hospital

Harvard Medical School

After a successful career in business, she followed a long-held dream to pursue a latent interest in science. During this mid-career change, she served in a research fellowship at Harvard Medical School in cancer genetics while obtaining her graduate degree. With the loss of many loved ones to cancer, she has been passionate about her work in early diagnosis and treatment of various cancers, including pancreatic, bladder, colon, breast, and leukemia. She was pleased to contribute in technical capacities at two renowned cancer centers. She has also found herself to be passionate about the execution and oversight of scientific projects. In this capacity, she has implemented genetics efforts extending beyond her core cancer expertise: infant hearing loss, clinical genetics, and the gamut of genetic sequencing efforts typical of the Broad Institute. She has an extensive network of contacts in the genomics community, and extensive knowledge of the details of running research and clinical genomic programs

Recent Publications

AnFiSA: An open-source computational platform for the analysis of sequencing data for rare genetic disease

Published On 2022 Aug 23

Journal article

Despite genomic sequencing rapidly transforming from being a bench-side tool to a routine procedure in a hospital, there is a noticeable lack of genomic analysis software that supports both clinical and research workflows as well as crowdsourcing. Furthermore, most existing software packages are not forward-compatible in regards to supporting ever-changing diagnostic rules adopted by the genetics community. Regular updates of genomics databases pose challenges for reproducible and traceable...


Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing

Published On 2017 May 21

Journal article

CONCLUSIONS: This study highlights the importance of the NGS-based gene panel testing approach in comprehensively identifying germline variants contributing to cancer predisposition and simultaneous detection of somatic and germline alterations.